Enhanced Population Cancer Care through Mainstream Genome Sequencing and Parent-of-Origin DetectionThis sequencing project will help improve cancer care for Canadians with hereditary cancer risk through enhanced, genomics-based screening. Abstract Less than 10 per cent of Canadians with hereditary cancer risk have been identified, due to under referral of eligible patients, limited capacity of cancer genetic services and low rates of cascade genetic testing. Several measures have been put in place in British Columbia and the Yukon to improve efficiencies and scale services. Universal multigene panel testing has standardized molecular genetic assessment across the main indications for service delivery since 2014 and has built experience with variants of uncertain significance and secondary findings. Introduction of Oncologist-initiated testing, and now "Mainstreamed testing" with providers returning the result, has enabled consent for genetic testing by non-genetics providers outside of BC Cancer's Hereditary Cancer Program (HCP) and has shown improved access, enhanced uptake, faster results and more equitable care. Oversight has been achieved through a lab-embedded genetic counselling team that reviews all mainstreamed testing and reflexively refer cases to HCP with positive...Access is restricted by the data custodian. The collection's description and structure are public; the data is not available for querying through this network.Enhanced Population Cancer Care through Mainstream Genome Sequencing and Parent-of-Origin Detection is published on Canadian Precision Health Initiative.