Genomics of Stroke and Cerebrovascular DiseaseThis sequencing project will help develop new more effective stroke prevention, risk assessment and precision diagnostic strategies for Canadians. Abstract More than 62,000 Canadians have a stroke each year. Stroke is the fifth leading cause of death and a leading cause of disability. Survivors often face long-term challenges such as physical disabilities, cognitive impairments and emotional distress. Stroke imposes a substantial economic burden, costing the Canadian economy $3.6 billion annually, including hospital care, rehabilitation and decreased productivity. Early prevention, timely treatment and precision diagnostics can help reduce these impacts. The central goal of this project is to use genomics and multiomics to develop novel, useful and impactful stroke prevention, risk assessment and precision diagnostic strategies for Canadians. The project will assess the genomes of 3,200 Canadian stroke patients, and for 2,000 of these patients, provide a detailed multiomic assessment (transcriptomics, proteomics, metabolomics and epigenetics). This world-leading work builds on existing collaborations with the International Stroke Genetics community. Of note, 2,000 of the stroke...Access is restricted by the data custodian. The collection's description and structure are public; the data is not available for querying through this network.Genomics of Stroke and Cerebrovascular Disease is published on Canadian Precision Health Initiative.