MOSAIC – Multi-Omics and Sonography to Advance Integrated Cardiac CareThis sequencing project will help accelerate diagnosis and intervention for patients at risk for cardiovascular disease. Abstract Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality in Canada, yet our ability to accurately predict and mitigate risk is still imperfect. Current genetic assessments for CVD risk often lack applicability across diverse populations, as many were developed using data from predominantly European cohorts. This limitation excludes large segments of the population, particularly those from underrepresented groups. Compounding this issue, individuals in rural, remote and underserved areas face barriers to early diagnosis and assessment due to limited access to physicians, geographic challenges, and a lack of diagnostic imaging. As a result, these individuals often present with advanced disease, leading to poorer outcomes and significantly higher healthcare costs. Our project will address these critical gaps. By capturing data from diverse populations across British Columbia (BC) and Yukon, we will enrich genetic datasets and develop a more inclusive framework for CVD risk prediction. We will implement a regional strategy to...Access is restricted by the data custodian. The collection's description and structure are public; the data is not available for querying through this network.MOSAIC – Multi-Omics and Sonography to Advance Integrated Cardiac Care is published on Canadian Precision Health Initiative.