This sequencing project will identify genetic and environmental risk factors for children and youth with mental health disorders, supporting earlier intervention. Abstract Mental health disorders (MHDs) typically begin early in life (75 per cent before the age of 25) affecting an estimated one in five children and youth (1.6 million Canadians). MHDs are highly heritable, and recent research has focused on identifying genetic risk and protective factors to inform effective approaches to risk stratification and targeted interventions. However, multiple barriers remain in realizing the promise of precision medicine in child and youth mental health, including small sample sizes, limited standardization of phenotyping or linkage to “real-world” (e.g. electronic health record, administrative health, patient reported) data and lack of representation from people of non-European ancestry potentially exacerbating existing health care inequities. To address these barriers, we propose a large-scale, collaborative Pan-Canadian initiative to link Genomic Environmental and Mental Health Data (Pan-GEM) to identify risk factors for MHDs. We will perform short-read whole genome sequencing on...
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Pan-Canadian Initiative Linking Genomic, Environmental and Mental Health Data in Children and Youth (Pan-GEM) is published on Canadian Precision Health Initiative.