Precision Health Network for Neurodevelopment, Mental Health and Brain InjuryThis sequencing project will help us better understand the genetic factors impacting children and youth with brain development conditions, such as neurodevelopmental conditions and acquired brain injury. Abstract Conditions impacting brain development in children and youth, such as neurodevelopmental conditions (NDDs) and acquired brain injury (ABI) are prevalent, impairing and costly. NDDs and related mental conditions impact at least one in five individuals, persist across the lifespan and cost up to two million dollars in lifetime cost per individual in Canada. ABI further impacts brain development, affecting 4.4 per cent of children 1-17 years, with up to a third of such injuries leading to persistent post-concussive symptoms. Despite recent advances in our understanding of the biology of these conditions, our ability to change long term outcomes remains limited. Accumulating data from sequencing studies highlights significant biological heterogeneity in NDDs, and emerging studies in ABI also suggest significant genomic heterogeneity. There is an urgent need to understand such heterogeneity, provide tailored anticipatory guidance, discover biomarkers that will allow patient...Access is restricted by the data custodian. The collection's description and structure are public; the data is not available for querying through this network.Precision Health Network for Neurodevelopment, Mental Health and Brain Injury is published on Canadian Precision Health Initiative.